The Effectos of Non-Pharmacological Interventions in Fibromyalgia: A Systematic Review and Metanalysis of Predominants Outcomes
Identifiers
URI: http://hdl.handle.net/20.500.12020/1274ISSN: 2277-9059
DOI: https://doi.org/10.3390/biomedicines11092367
Author/s
Hong-Baik, Isabel; Úbeda-D'Ocasar, Edurne; Cimadevilla-Fernández-Pola, Eduardo; Jiménez-Díaz-Benito, Víctor; Hervás-Pérez, Juan PabloDate
2023-08-24Document type
articleÁrea/s de conocimiento
FisioterapiaMateria/s Unesco
3209 FarmacologíaAbstract
Abstract: (1) Fibromyalgia (FM) is a chronic musculoskeletal condition with multiple symptoms
primarily affecting women. An imbalance in cytokine levels has been observed, suggesting a chronic
low-grade inflammation. The main aim of the meta-analysis was to examine the effect of multimodal
rehabilitation on cytokine levels and other predominant variables in patients with FM. Furthermore,
to examine which non-pharmacological tools have been used to investigate the effects that these can
have on cytokines in FM patients. (2) Methods: Searches were conducted in PubMed, Scopus, Web of
Science, Cochrane, and ScienceDirect databases. This systematic review and metanalysis followed the
PRISMA statement protocol. The methodological quality of the studies was assessed using the PEDro
scale, the risk of bias followed the Cochrane Manual 5.0.1, and the GRADE system was used for rating
the certainty of evidence. (3) Results: Of 318 studies found, eight were finally selected, with a sample
size of 320 women with a mean age of 57 20. The proinflammatory cytokines IL-1 , IL-6, IL-8 and
TNF- were the most studied. Resistance exercise, aquatic exercise, dynamic contractions, cycling,
treadmill, and infrared therapy were the main non-pharmacological tools used. (4) Conclusions:
The systematic review with meta-analysis found evidence of elevated cytokine levels in patients with
FM, suggesting low chronic inflammation and a possible contribution to central sensitization and
chronic pain. However, the effects of physiotherapeutic interventions on cytokine levels are variable,
highlighting the importance of considering different factors and the need for further research.