Epigenomics of Alzheimer’s Disease
Identificadores
URI: http://hdl.handle.net/20.500.12020/763ISSN: 1878-3317
DOI: 10.1016/j.jecm.2014.03.010
Fecha
2014-04-29Tipo de documento
articleÁrea/s de conocimiento
PsicologíaMateria/s Unesco
61 PsicologíaResumen
Alzheimer's disease (AD) is a polygenic/complex disorder in which genomic, epigenomic, and environmental factors are involved. Epigenetic factors have emerged as important mediators of aging, neurodegeneration, and brain disorders. Epigenomic changes underlying the phenotypic expression of AD, represented by deposits of extracellular Aβ aggregates in senile plaques, intracellular neurofibrillary tangles, neuronal loss, dendritic desarborization, and neurochemical alterations are candidate targets for therapeutic intervention. Changes in DNA methylation, histone modifications, chromatin remodeling, and noncoding RNA dysregulation can affect AD-related gene expression, leading to the multistep process of premature neurodegeneration. Epigenetic modifications are reversible and can be potentially targeted by pharmacological and dietary interventions.