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CFTR genotype-related body water and electrolyte balance during a marathon
dc.contributor.author | Del Coso, J. | |
dc.contributor.author | Lara, B | |
dc.contributor.author | Salinero, J.J. | |
dc.contributor.author | Areces, F. | |
dc.contributor.author | Ruiz-Vicente, D. | |
dc.contributor.author | Gallo-Salazar, C. | |
dc.contributor.author | Abián-Vicen, J. | |
dc.contributor.author | Cacabelos, Ramón | |
dc.date.accessioned | 2017-09-08T08:33:58Z | |
dc.date.available | 2017-09-08T08:33:58Z | |
dc.date.issued | 2016-09 | |
dc.identifier.citation | Del Coso, J., Lara, B., Salinero, J. J., Areces, F., Ruiz-Vicente, D., Gallo-Salazar, C., Abián-Vicén, J. and Cacabelos, R. (2016), CFTR genotype-related body water and electrolyte balance during a marathon. Scand J Med Sci Sports, 26: 1036–1044 | es |
dc.identifier.uri | http://hdl.handle.net/20.500.12020/394 | |
dc.description.abstract | The aim of this investigation was to determine the influence of CFTR genotype on body water and electrolyte balance during a marathon. Fifty-one experienced runners completed a marathon race. Before and after the race, body mass and a sample of venous blood were obtained. During the race, sweat samples were collected using sweat patches, and fluid and electrolyte intake were obtained using self-reported questionnaires. Thirty-eight participants (74.5% of the total) were 7T/7T homozygotes, 11 (21.6%) were 7T/9T heterozygotes, and one participant presented the rare genotype 5T/7T. Another participant with 9T/9T presented the mutation p.L206W. Participants with 7T/7T showed higher sweat sodium concentrations (42.2 ± 21.6 mmol/L) than 7T/9T (29.0 ± 24.7 mmol/L; P = 0.04). The runner with the 5T/7T genotype (10.2 mmol/L) and the participant with the p.L206W mutation (20.5 mmol/L) exhibited low-range sweat sodium concentrations. However, post-race serum sodium concentration was similar in 7T/7T and 7T/9T (142.1 ± 1.3 and 142.4 ± 1.6 mmol/L, respectively; P = 0.27) and did not show abnormalities in participants with the 5T/7T genotype (140.0 mmol/L) and the p.L206W mutation (143.0 mmol/L). Runners with the CFTR-7T/7T genotype exhibited increased sweat sodium concentrations during a marathon. However, this phenotype was not related with increased likelihood of suffering body water and electrolyte imbalances during real competitions. | es |
dc.language.iso | en | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | CFTR genotype-related body water and electrolyte balance during a marathon | es |
dc.type | article | es |
dc.identifier.doi | 10.1111/sms.12542 | |
dc.issue.number | 9 | es |
dc.journal.title | Scand J Med Sci Sports | es |
dc.page.initial | 1036 | es |
dc.page.final | 1044 | es |
dc.rights.accessRights | embargoedAccess | es |
dc.subject.area | Ciencias de la Actividad Física y del Deporte | es |
dc.subject.keyword | Sweat | es |
dc.subject.keyword | chloride | es |
dc.subject.keyword | cystic fibrosis | es |
dc.subject.keyword | endurance exercise | es |
dc.subject.keyword | hyponatremia | es |
dc.subject.keyword | salt | es |
dc.subject.unesco | 3201.99 Otras | |
dc.volume.number | 26 | es |
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