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The Presence of Pretransplant Antiphospholipid Antibodies IgA Anti-b-2-Glycoprotein I as a Predictor of Graft Thrombosis After Renal Transplantation
dc.contributor.author | Serrano, Manuel | |
dc.contributor.author | Morales, Jose M | |
dc.contributor.author | martinez-flores, jose angel | |
dc.contributor.author | Perez, Dolores | |
dc.contributor.author | Castro, Maria Jose | |
dc.contributor.author | Sanchez, Elena | |
dc.contributor.author | Garcia, Florencio | |
dc.contributor.author | Rodriguez Antolin, Alfredo | |
dc.contributor.author | Alonso, Marina | |
dc.contributor.author | Gutierrez, Eduardo | |
dc.contributor.author | Morales, Enrique | |
dc.contributor.author | Praga, Manuel | |
dc.contributor.author | Gonzalez, Esth | |
dc.contributor.author | Andres, Amado | |
dc.contributor.author | Paz-Artal, Estela | |
dc.contributor.author | Martinez, Miguel Angel | |
dc.contributor.author | Serrano, Antonio | |
dc.date.accessioned | 2024-02-06T16:26:16Z | |
dc.date.available | 2024-02-06T16:26:16Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Manuel Serrano; Jose Maria Morales; Jose Angel Martínez Flores; Dolores Pérez; Maria José Castro; Elena Sánchez; Florencio García; Alfredo Rodríguez Antolín; Marina Alonso; Eduardo Gutierrez; Enrique Morales; Manuel Praga; Esther González; Amado Andrés; Estela Paz Artal; Miguel Angel Martínez; Antonio Serrano. TRANSPLANTATION, 101 (3), pp. 597-607. DOI: 10.1097/TP.0000000000001199. | es |
dc.identifier.issn | 0041-1337 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12020/1304 | |
dc.description.abstract | Background. Vessel thrombosis is a severe complication after renal transplantation. Antibodies anti-β-2 glycoprotein-I of IgA isotype (IgA-aB2GP1) have been linked to thrombotic events and mortality in hemodialysis patients. Methods. All kidney transplanted patients from 2000 to 2011 (n = 1375) in our hospital were followed up for 2 years, evaluating 3 time periods. Results. At transplantation, 401 patients were positive for IgA-aB2GPI (29.2%, group 1), and the remaining patients were negative (group 2). Graft loss at 6 months posttransplantation was higher in group 1 (18% vs 7.2%; P < 0.001). The most frequent cause of early graft loss was vessel thrombosis, especially in group 1 (12.2% vs 2.6% of patients; P < 0.001). In fact, vessel thrombosis was the most important cause of graft loss in the 3 time periods, irrespective of demographic changes and introduction of transplantation with asystolic donors. Notably, IgA-aB2GP1 was an independent risk factor for graft thrombosis (odds ratio, 5.047; P < 0.001). Furthermore, the presence of IgA-aB2GP1 was associated with early graft loss and delayed graft function. Mortality at 24 months was also higher in group 1. Conclusions. In conclusion, pretransplant IgA-aB2GP1 was the main risk factor for graft thrombosis and early graft loss. Further research should be made on whether anticoagulation in antibody-positive patients could ameliorate this catastrophic complication | es |
dc.description.sponsorship | Fondo de Investigaciones Sanitarias and cofinanced by European Regional Development Fund (grants: PI12-0108, PIE13/0045 and PI14-0360) | es |
dc.language.iso | en | es |
dc.title | The Presence of Pretransplant Antiphospholipid Antibodies IgA Anti-b-2-Glycoprotein I as a Predictor of Graft Thrombosis After Renal Transplantation | es |
dc.type | article | es |
dc.identifier.doi | https://doi.org/10.1097/TP.0000000000001199 | |
dc.issue.number | 3 | es |
dc.journal.title | TRANSPLANTATION | es |
dc.page.initial | 597 | es |
dc.page.final | 607 | es |
dc.rights.accessRights | openAccess | es |
dc.subject.area | Ciencias Biomédicas | es |
dc.subject.unesco | 32 Ciencias Médicas | es |
dc.volume.number | 101 | es |
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