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Mixed bloodstream infections involving bacteria and Candida spp
dc.contributor.author | Bouza, Emilio | |
dc.contributor.author | Burillo, Almudena | |
dc.contributor.author | Muñoz, Patricia | |
dc.contributor.author | Guinea, Jesus | |
dc.contributor.author | Marin, Mercedes | |
dc.contributor.author | Rodriguez-Creixems, Marta | |
dc.date.accessioned | 2024-02-06T15:36:32Z | |
dc.date.available | 2024-02-06T15:36:32Z | |
dc.date.issued | 2013-08-01 | |
dc.identifier.citation | Bouza, E., Burillo, A., Muñoz, P., Guinea, J., Marín, M., & Rodríguez-Créixems, M. (2013). Mixed bloodstream infections involving bacteria and Candida spp. The Journal of antimicrobial chemotherapy, 68(8), 1881–1888. https://doi.org/10.1093/jac/dkt099 | es |
dc.identifier.issn | 0305-7453 | |
dc.identifier.other | https://academic.oup.com/jac | es |
dc.identifier.other | https://watermark.silverchair.com/dkt099.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAA0swggNHBgkqhkiG9w0BBwagggM4MIIDNAIBADCCAy0GCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMx-2Ub4oh4u1xs7-nAgEQgIIC_moicdJv5tOkdR97rWcfEMW59iuYZIofXJLfmSHG6lc6cTtWUdfkbmB9GmIvzTPEbErQFIAz_ALu6MrmHwILQrSG3h8VJXhc864UViR_hqcAeSpxmUIAKDdUgo1UEhFlYQ4u36m6ZPP4UeRhfVFesp566HqyBinneLkoJ7kzU37nCVQ_AG5eG6rrM4CJIwlzTbtylj_0YVL3pJiHKseTFUtxSQqbmeGJjelHpqhDBvBfABEniEKWVRtNVBTDNigBhKMD2tpvUve-oaxdkFzcJ8i01bEhxQlYC8B_Ov03VRe60V3DbLUZhb3d9KbRODSUGk0PvoV108PRRRnEpk4dmRGkiJ6wnA77u5OmFM5LDld7PCJ9z6Ys39hAN1iWfnR7YeK-1CiLTu0Osy4PiqORQDgZRjQKSn01iJg7FuJpcxa1mzSZuNQG2lJ19H9rZs3nDtZGw7clJMgTyaPltx4-ITa3GJW9m7iyHkLkiwwWayvGctIGK5dlDFJBNogkCvqYRoswN9d3x-6IgkWof3UzF4JYKg-3vK2eBV52zl8c2-H_xrXFmWHUnP5Q5VDhJWSfEULkjuT0pBymLmrpKh0J1gS6_kJQqdslNDO_rUYR2_EcCRCFQwr21ykZyT_AFlnUEok6FA4PPqRC3TPJZfYeU1Jk78cO6AHtE9ITiK2vkWao3XeIKni_K-iWTyKdVZkxAhZhAjV-TEZ9simDEcAL0iHgOqkxBgw2aqAsCWo-HxuSg7fLwSiaQQvhJaGifjJ3uc75Z9JuByW18kjiAqBRvzjrzDzy5CCfqPo5bsnAKdGVMOUDmxHQIszcE39anw7z2gLBet-_ky_FFwp4CZ5IyTZ3leF6tRLK-TrrAno-Lhk65CKkRcqGt9FfYnMExSknvSNgltJ8a4DoOVNoAFWZfsq1-nkSS0X9yf2Ie6GLghg5vcftESaaCEXe0t-bThJjGQOGBIxkt1mZH0VFlTr6xAfGAGKhUuB2tb1Pdv2Kc-Ek_G5hH6wjxw8B-jJkvi4 | es |
dc.identifier.uri | http://hdl.handle.net/20.500.12020/1287 | |
dc.description.abstract | Objectives: Polymicrobial bloodstream infection (BSI) is an imprecisely defined entity purportedly associated with a worse outcome than monomicrobial BSI. This study examines trends in BSI episodes caused by bacteria and Candida spp. (mixed-BSI) in a large teaching hospital. Methods: All episodes of BSI from January 2000 to December 2010 were reviewed. Three groups (n=54 each) of patients were compared: all adults with mixed-BSI from January 2006 to December 2010 (cases) and randomly selected patients with polybacterial BSI (polyB-BSI) (Control 1) or Candida spp. BSI (Candida-BSI) (Control 2) in this same period. Results: A total of 139 episodes of mixed-BSI were recorded (0.7% of all BSI, 6.9% of all poly-BSI and 18.0% of all Candida-BSI episodes). The incidence of mixed-BSI was 0.21 cases/1000 admissions, increasing from 0.08 (2000) to 0.34 (2010) cases/1000 admissions (P¼0.007). Mixed-BSI represented 11.8% and 22.9% of all episodes of candidaemia in 2000 and 2010, respectively (P¼0.011). Compared with polyB-BSI, mixed-BSI patients showed fewer malignancies, more frequent nosocomial or intravenous catheter BSI source and less frequent intra-abdominal origin, were more frequently admitted to an intensive care unit (ICU), received more antimicrobials and showed a longer hospital stay and higher mortality. Compared with Candida-BSI, mixed-BSI patients showed more severe underlying diseases, were more frequently admitted to an ICU or oncology-haematology unit, showed a higher APACHE II score, more often progressed to septic shock or multiorgan failure and received more antimicrobials. Mortality was similar. Conclusions: Mixed-BSI is a rare, distinct infection with a worse prognosis than polyB-BSI. We were unable to detect differences in the prognosis of mixed-BSI when compared with Candida-BSI. | es |
dc.language.iso | en | es |
dc.publisher | Oxford Univ press | es |
dc.title | Mixed bloodstream infections involving bacteria and Candida spp | es |
dc.type | article | es |
dc.identifier.doi | 10.1093/jac/dkt099 | |
dc.issue.number | 8 | es |
dc.journal.title | Journal of Antimicrobial Chemotherapy | es |
dc.page.initial | 1881 | es |
dc.page.final | 1888 | es |
dc.relation.projectID | This study was funded in part by the Programa de Centros de Investigación Biomédica en Red (CIBER) de Enfermedades Respiratorias CB06/ 06/0058 and by a project awarded by the Fundacio´n Mutua Madrileña, Madrid, Spain (‘Candidemia: confirmación o exclusión del catéter venoso central como origen de la misma’, 2009–10). | es |
dc.rights.accessRights | embargoedAccess | es |
dc.subject.area | Ciencias Biomédicas | es |
dc.subject.keyword | Bacteraemia | es |
dc.subject.keyword | Candidaemia | es |
dc.subject.keyword | Polymicrobial bacteraemia | es |
dc.subject.keyword | Polymicrobial candidaemia | es |
dc.subject.keyword | Coinfection | es |
dc.subject.unesco | 3201.03 Microbiología Clínica | es |
dc.volume.number | 68 | es |
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