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Is Candida colonization of central vascular catheters in non-candidemic, non-neutropenic patients an indication for antifungals?
dc.contributor.author | Perez-Parra, Alfonso | |
dc.contributor.author | Muñoz, Patricia | |
dc.contributor.author | Guinea, Jesus | |
dc.contributor.author | Martin-Rabadan, Pablo | |
dc.contributor.author | Guembe, Maria | |
dc.contributor.author | Bouza, Emilio | |
dc.date.accessioned | 2024-02-06T12:23:52Z | |
dc.date.available | 2024-02-06T12:23:52Z | |
dc.date.issued | 2009 | |
dc.identifier.citation | Pérez-Parra, A., Muñoz, P., Guinea, J., Martín-Rabadán, P., Guembe, M., & Bouza, E. (2009). Is Candida colonization of central vascular catheters in non-candidemic, non-neutropenic patients an indication for antifungals?. Intensive care medicine, 35(4), 707–712. https://doi.org/10.1007/s00134-009-1431-6 | es |
dc.identifier.issn | 0342-4642 | |
dc.identifier.other | https://www.springer.com/journal/134 | es |
dc.identifier.uri | http://hdl.handle.net/20.500.12020/1261 | |
dc.description.abstract | Purpose: To assess the influence of antifungal therapy on the outcome of non-candidemic adult patients with central vascular catheter (CVC) tips colonized by Candida species. Methods: A retrospective analysis of the outcome of patients with Candida colonization of their CVC tip and no concurrent candidemia was made over a 4-year period. Patients who either died or developed candidemia-invasive candidiasis (poor outcome) were compared with those who improved. Results: We finally included 58 patients for analysis. Almost all (91.4%) had to be admitted to the ICU during their hospital stay. Independent predictors for outcome were a McCabe and Jackson score corresponding to ultimately fatal underlying disease [odds ratio (OR) 11.98; 95% confidence interval (CI), 1.37-104.97; P = 0.02], and maximum severity corresponding to severe sepsis, septic shock or multiorgan failure (OR: 6.16, CI 95%: 1.00-37.93; P = 0.05). We were unable to demonstrate that antifungal therapy was an independent variable influencing outcome (OR 0.82; 95% CI, 0.27-2.47; P = 0.73). Conclusions: Our data suggest that, in non-neutropenic critically ill patients with no concomitant candidemia and with CVC tips colonized by Candida, antifungal therapy does not seem to have a significant influence on clinical outcome. | es |
dc.language.iso | en | es |
dc.publisher | SPRINGER | es |
dc.title | Is Candida colonization of central vascular catheters in non-candidemic, non-neutropenic patients an indication for antifungals? | es |
dc.type | article | es |
dc.identifier.doi | 10.1007/s00134-009-1431-6 | |
dc.issue.number | 4 | es |
dc.journal.title | Intensive Care Medicine | es |
dc.page.initial | 707 | es |
dc.page.final | 712 | es |
dc.relation.projectID | Financial support: Alfonso Pe´rez Parra MD is contracted by the Fundacio´n para la Investigacio´n Biome´dica del Hospital General Universitario Gregorio Maran˜o´n and Fondo de Investigacio´n Sanitaria (FIS) CM06/00037. Jesu´s Guinea is contracted by the Fundacio´n para la Investigacio´n Biome´dica del Hospital General Universitario Gregorio Maran˜o´n and Fondo de Investigacio´n Sanitaria (FIS) CM05/00171. Patricia Mun˜oz and Emilio Bouza collaborate with the Red Espan˜ola de Investigacio´n en Patologı´a Infecciosa (REIPI), RD06/0008/1025. | es |
dc.rights.accessRights | embargoedAccess | es |
dc.subject.area | Ciencias Biomédicas | es |
dc.subject.keyword | Central vascular catheters | es |
dc.subject.keyword | Candidemia | es |
dc.subject.keyword | Invasive candidiasis | es |
dc.subject.keyword | Catheter tip colonization | es |
dc.subject.keyword | Antifungal agents | es |
dc.subject.keyword | Critically ill patients | es |
dc.subject.unesco | 3201.03 Microbiología Clínica | es |
dc.volume.number | 35 | es |
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