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Association of Early Kidney Allograft Failure with Preformed IgA Antibodies to β2-Glycoprotein I
dc.contributor.author | Morales, Jose M | |
dc.contributor.author | martinez-flores, jose angel | |
dc.contributor.author | Serrano, Manuel | |
dc.contributor.author | Castro, Maria Jose | |
dc.contributor.author | Alfaro, Francisco Javier | |
dc.contributor.author | Garcia, Florencio | |
dc.contributor.author | Martinez, Miguel Angel | |
dc.contributor.author | Andres, Amado | |
dc.contributor.author | Gonzalez, Esther | |
dc.contributor.author | Praga, Manuel | |
dc.contributor.author | Paz-Artal, Estela | |
dc.contributor.author | Serrano, Antonio | |
dc.date.accessioned | 2024-02-06T12:06:52Z | |
dc.date.available | 2024-02-06T12:06:52Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Jose M Morales; Jose Angel Martinez Flores; Manuel Serrano; Maria José Castro; Francisco Javier Alfaro; Florencio García; Miguel Angel Martínez; Amado Andrés; Esther González; Manuel Praga; Estela Paz Artal; Antonio Serrano. Association of Early Kidney Allograft Failure with Preformed IgA Antibodies to β2-Glycoprotein I. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 26 (3), pp. 735-745. | es |
dc.identifier.other | https://journals.lww.com/jasn/fulltext/2015/03000/association_of_early_kidney_allograft_failure_with.25.aspx | es |
dc.identifier.other | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341482/ | es |
dc.identifier.uri | http://hdl.handle.net/20.500.12020/1257 | |
dc.description.abstract | In the current immunosuppressive therapy era, vessel thrombosis is themost common cause of early graft loss after renal transplantation. The prevalence of IgA anti–b2-glycoprotein I antibodies (IgA-aB2GPI-ab) in patients on dialysis is elevated (.30%), and these antibodies correlate with mortality and cardiovascular morbidity. To evaluate the effect of IgA-aB2GPI-ab in patients with transplants, we followed all patients transplanted from2000 to 2002 in the Hospital 12 deOctubre prospectively for 10 years. Presence of IgAaB2GPI- ab in pretransplant serum was examined retrospectively. Of 269 patients, 89 patients were positive for IgA-aB2GPI-ab (33%; group 1), and the remaining patientswere negative (67%; group 2).Graft loss at 6months post-transplant was significantly higher in group 1 (10 of 89 versus 3 of 180 patients in group 2; P=0.002). Themost frequent cause of graft loss was thrombosis of the vessels, which was observed only in group 1 (8 of 10 versus 0 of 3 patients in group 2; P=0.04). Multivariate analysis showed that the presence of IgA-aB2GPI-ab was an independent risk factor for early graft loss (P=0.04) and delayed graft function (P=0.04). There were no significant differences regarding patient survival between the two groups. Graft survival was similar in both groups after 6 months. In conclusion, patients with pretransplant IgA-aB2GPIab have a high risk of early graft loss caused by thrombosis and a high risk of delayed graft function. Therefore, pretransplant IgA-aB2GPI-ab may have a detrimental effect on early clinical outcomes after renal transplantation. | es |
dc.description.sponsorship | Mutua Madrileña 2008-090 y Fondo de Investigaciones Sanitarias Grants PS09- 02023 and PI12-00108. | es |
dc.description.sponsorship | Mutua Madrileña 2008-090 and Fondo de Investigaciones Sanitarias Grants PS09- 02023 and PI12-00108. | es |
dc.language.iso | en | es |
dc.publisher | Elsevier | es |
dc.title | Association of Early Kidney Allograft Failure with Preformed IgA Antibodies to β2-Glycoprotein I | es |
dc.type | article | es |
dc.identifier.doi | 10.1681/ASN.2014030228 | |
dc.issue.number | 3 | es |
dc.journal.title | Kidney international | es |
dc.page.initial | 735 | es |
dc.page.final | 745 | es |
dc.rights.accessRights | openAccess | es |
dc.subject.area | Ciencias Biomédicas | es |
dc.subject.keyword | Survival | es |
dc.subject.keyword | Immunology | es |
dc.subject.keyword | Kidney transplantation | es |
dc.subject.unesco | 32 Ciencias Médicas | es |
dc.volume.number | 26 | es |