Mostrar el registro sencillo del ítem
Levodopa-Induced Dyskinesia Is Associated with Increased Thyrotropin Releasing Hormone in the Dorsal Striatum of Hemi-Parkinsonian Rats
| dc.contributor.author | Cantuti Castelvetri, Ippolita | |
| dc.contributor.author | F. Hernandez, Ledia | |
| dc.contributor.author | Keller-McGandy, Christine E | |
| dc.contributor.author | Kett, Lauren E. | |
| dc.contributor.author | Landy, Alex | |
| dc.contributor.author | Hollingsworth, Zane R | |
| dc.contributor.author | Saka, Esen | |
| dc.contributor.author | Crittenden, Jill R | |
| dc.contributor.author | Nillni, Eduardo A | |
| dc.contributor.author | Young, Anne B | |
| dc.contributor.author | Standaert, David G | |
| dc.contributor.author | Graybiel, Ann M | |
| dc.date.accessioned | 2024-02-06T10:00:18Z | |
| dc.date.available | 2024-02-06T10:00:18Z | |
| dc.date.issued | 2010-11-10 | |
| dc.identifier.citation | Cantuti-Castelvetri, I., Hernandez, L. F., Keller-McGandy, C. E., Kett, L. R., Landy, A., Hollingsworth, Z. R., Saka, E., Crittenden, J. R., Nillni, E. A., Young, A. B., Standaert, D. G., & Graybiel, A. M. (2010). Levodopa-induced dyskinesia is associated with increased thyrotropin releasing hormone in the dorsal striatum of hemi-parkinsonian rats. PloS one, 5(11), e13861. https://doi.org/10.1371/journal.pone.0013861 | es |
| dc.identifier.issn | 1932-6203 | |
| dc.identifier.other | journals.plos.org/plosone/article?id=10.1371/journal.pone.0013861 | es |
| dc.identifier.other | https://doi.org/10.1371/journal.pone.0013861 | es |
| dc.identifier.uri | http://hdl.handle.net/20.500.12020/1219 | |
| dc.description.abstract | Dyskinesias associated with involuntary movements and painful muscle contractions are a common and severe complication of standard levodopa (L-DOPA, L-3,4-dihydroxyphenylalanine) therapy for Parkinson's disease. Pathologic neuroplasticity leading to hyper-responsive dopamine receptor signaling in the sensorimotor striatum is thought to underlie this currently untreatable condition. | es |
| dc.description.sponsorship | This study was supported in part by the MGH/MIT Morris Udall Center of Excellence in PD Research (NIH NS38372) (ICC, LRK, ZRH, ABY, LFH, AMG, CEK-McG, JRC), and the American Parkinson Disease Association Advanced Centers for Parkinson Research at Massachusetts General Hospital (ICC, ABY) and University of Alabama Birmingham (DGS); NIDDK/NIH grant R01 DK58148 and R01 NINDS/NIH grant NS045231 (EAN); Stanley H. and Sheila G. Sydney Fund (AMG); Parkinson's Disease Foundation Fellowship and Fulbright Fellowship (LFH); Michael J. Fox Foundation (AMG, JRC). | es |
| dc.language.iso | en | es |
| dc.publisher | Public Library of Science (PLOS) | es |
| dc.title | Levodopa-Induced Dyskinesia Is Associated with Increased Thyrotropin Releasing Hormone in the Dorsal Striatum of Hemi-Parkinsonian Rats | es |
| dc.type | article | es |
| dc.identifier.doi | https://doi.org/10.1371/journal.pone.0013861 | |
| dc.issue.number | 11 | es |
| dc.journal.title | Plos One | es |
| dc.page.initial | e13861 | es |
| dc.page.final | e13861 | es |
| dc.relation.projectID | NIDDK/NIH grant R01 DK58148 and R01 NINDS/NIH grant NS045231 | es |
| dc.rights.accessRights | openAccess | es |
| dc.subject.area | Ciencias Biomédicas | es |
| dc.subject.keyword | Levodopa-indiced dyskinesias | es |
| dc.subject.keyword | Tyrotrophin releasing hormone (TRH) | es |
| dc.subject.keyword | Dorsal striatum | es |
| dc.subject.keyword | Hemi-parkinsonian rats | es |
| dc.subject.unesco | 32 Ciencias Médicas | es |
| dc.subject.unesco | 2490.02 Neuroquímica | es |
| dc.volume.number | 5 | es |
