Aspergillus fumigatus Strains with Mutations in the cyp51A Gene Do Not Always Show Phenotypic Resistance to Itraconazole, Voriconazole, or Posaconazole
Identificadores
URI: http://hdl.handle.net/20.500.12020/1211ISSN: 0066-4804
DOI: 10.1128/AAC.01358-10
Fecha
2011-02-14Tipo de documento
articleÁrea/s de conocimiento
Ciencias BiomédicasMateria/s Unesco
2414 MicrobiologíaResumen
We performed molecular identification of 98 Aspergillus fumigatus complex isolates with MICs of 1 to 4 μg/ml for itraconazole and searched for the presence of mutations in cyp51A. Most of the isolates (91%) belonged to A. fumigatus sensu stricto. We found 14 different mutations in nine isolates at codons different from G54, M220, G138, G448, and L98. We report new mutations at positions 165, 262, 479, and 497 (silent). The role of these mutations should be analyzed