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Effect of streptozotocin diabetes on the glycolytic flux and on fructose 2,6-bisphosphate levels in isolated rat enterocytes
dc.contributor.author | Rossi, Irma | |
dc.contributor.author | Sánchez-Arias, Juan Antonio | |
dc.contributor.author | Felíu, Juan Emilio | |
dc.date.accessioned | 2024-02-05T17:54:11Z | |
dc.date.available | 2024-02-05T17:54:11Z | |
dc.date.issued | 1990 | |
dc.identifier.citation | Rossi, I., Sánchez-Arias, J. A., & Felíu, J. E. (1990). Effect of streptozotocin diabetes on the glycolytic flux and on fructose 2,6-bisphosphate levels in isolated rat enterocytes. Metabolism: clinical and experimental, 39(8), 882–885. https://doi.org/10.1016/0026-0495(90)90137-2 | es |
dc.identifier.issn | 0026-0495 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12020/1202 | |
dc.description.abstract | In epithelial cells isolated from rat small intestine and incubated in the presence of 1 mM glucose, streptozotocin-induced diabetes reduced, by 46 and 29%, respectively, the rates of both glucose utilization and L-lactate formation. These effects were accompanied by a significant decrease of enterocyte fructose 2,6-bisphosphate concentration (about 50%) and of the glycolytic flux through the reaction catalyzed by 6-phosphofructo 1-kinase. The diminution of enterocyte fructose 2,6-bisphosphate levels caused by diabetes occurred in spite of an increase of hexose 6-phosphate concentration, and was associated with a reduction in the amount of active form of 6-phosphofructo 2-kinase; total activity of this enzyme was not significantly modified. Diabetes also caused an acceleration in the rate of 3-O-methyl-D-(14C) glucose uptake and increased hexokinase activity in enterocytes. Lactate dehydrogenase, pyruvate kinase and 6-phosphofructo 1-kinase activities were not found to be significantly different in epithelial cells isolated from control or diabetic animals. Our results indicate that a reduction of the glycolytic flux in enterocytes could collaborate to increase intestinal glucose absorption in the diabetic state. | es |
dc.language.iso | en | es |
dc.publisher | Elsevier | es |
dc.title | Effect of streptozotocin diabetes on the glycolytic flux and on fructose 2,6-bisphosphate levels in isolated rat enterocytes | es |
dc.type | article | es |
dc.identifier.doi | https://doi.org/10.1016/0026-0495(90)90137-2 | |
dc.identifier.essn | 1532-8600 | |
dc.issue.number | 8 | es |
dc.journal.title | Metabolism | es |
dc.page.initial | 882 | es |
dc.page.final | 885 | es |
dc.rights.accessRights | embargoedAccess | es |
dc.subject.area | Ciencias Biomédicas | es |
dc.subject.keyword | streptozotocin diabetes | es |
dc.subject.keyword | fructose 2,6-bisphosphate | es |
dc.subject.keyword | enterocytes | es |
dc.subject.unesco | 24 Ciencias de la Vida | es |
dc.volume.number | 39 | es |
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