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Fluconazole-resistant Candida parapsilosis clonally related genotypes: first report proving the presence of endemic isolates harbouring the Y132F ERG11 gene substitution in Spain
dc.contributor.author | Alcoceba, Eva | |
dc.contributor.author | Gómez, Ana | |
dc.contributor.author | Lara-Esbrí, Paula | |
dc.contributor.author | Oliver, Antonio | |
dc.contributor.author | Ferre Beltrán, Adrián | |
dc.contributor.author | Ayestarán, Ignacio | |
dc.contributor.author | Muñoz, Patricia | |
dc.contributor.author | Escribano, Pilar | |
dc.contributor.author | Guinea, Jesús | |
dc.date.accessioned | 2024-02-05T10:57:17Z | |
dc.date.available | 2024-02-05T10:57:17Z | |
dc.date.issued | 2022-04-16 | |
dc.identifier.citation | Alcoceba, E., Gómez, A., Lara-Esbrí, P., Oliver, A., Beltrán, A. F., Ayestarán, I., Muñoz, P., Escribano, P., & Guinea, J. (2022). Fluconazole-resistant Candida parapsilosis clonally related genotypes: first report proving the presence of endemic isolates harbouring the Y132F ERG11 gene substitution in Spain. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 28(8), 1113–1119. https://doi.org/10.1016/j.cmi.2022.02.025 | es |
dc.identifier.other | https://pubmed.ncbi.nlm.nih.gov/35439634/ | es |
dc.identifier.uri | http://hdl.handle.net/20.500.12020/1171 | |
dc.description.abstract | Objectives: We report here for the first time the presence of Candida parapsilosis isolates harbouring the Y132F ERG11 gene substitution in patients admitted to a Spanish hospital. Methods: We studied the available (n = 104) C parapsilosis isolates from patients admitted to the Son Espases reference hospital in the Balearic Islands from 1 April 2019 to 30 November 2020. Isolates were sourced from 70 patients: catheter (n = 41), blood cultures (n = 37), lower respiratory tract (n = 15), intra-abdominal (n = 8), and other samples (n = 3). Isolates were genotyped and tested for antifungal susceptibilities to amphotericin B, triazoles, anidulafungin, and micafungin using EUCAST E.Def 7.3.2. The ERG11 gene was sequenced in fluconazole-resistant isolates. Results: Among the 104 isolates, fluconazole and voriconazole resistance was found in 87 (84%) and 30 (29%) isolates, respectively; all isolates were fully susceptible to echinocandins and amphotericin B. All fluconazole-resistant isolates harboured the Y132F substitution in the ERG11 gene and were grouped into 11 clonally related genotypes. A genotype accounted for 70% (61/87) of fluconazole-resistant isolates. Genotypes involving the fluconazole-resistant isolates were different from those found in the remaining fluconazole-susceptible genotypes. Fifty-six patients harboured fluconazole-resistant genotypes, and 35 of the 56 had candidaemia (48%), abdominal candidiasis (17%), or other forms of candidiasis (35%). Only 20% of the study patients infected by fluconazole-resistant genotypes had a history of azole use. Discussion: Fluconazole resistance in C parapsilosis isolates from patients admitted to this reference hospital is not attributable to prior azole use, but rather to the presence of a group of fluconazole-resistant C parapsilosis genotypes that have become endemic | es |
dc.language.iso | en | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | Fluconazole-resistant Candida parapsilosis clonally related genotypes: first report proving the presence of endemic isolates harbouring the Y132F ERG11 gene substitution in Spain | es |
dc.type | article | es |
dc.identifier.doi | 10.1016/j.cmi.2022.02.025 | |
dc.issue.number | 8 | es |
dc.journal.title | Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases | es |
dc.page.initial | 1113 | es |
dc.page.final | 119 | es |
dc.relation.projectID | This work was supported by grants PI18/01155 and PI19/01012 from Fondo de Investigaci on Sanitaria (FIS. Instituto de Salud Carlos III. Plan Nacional de IþDþI 2017-2020). The study was cofunded by the European Regional Development Fund ‘A way of making Europe.’ | es |
dc.rights.accessRights | embargoedAccess | es |
dc.subject.area | Ciencias Biomédicas | es |
dc.subject.keyword | Candida parapsilosis | es |
dc.subject.keyword | EUCAST E.Def 7.2.3 | es |
dc.subject.keyword | Fluconazole | es |
dc.subject.keyword | Resistance | es |
dc.subject.keyword | Y132F | es |
dc.subject.unesco | 2414 Microbiología | es |
dc.volume.number | 28 | es |
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