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Detection of SARS‑CoV‑2 antibodies is insufficient for the diagnosis of active or cured COVID‑19
dc.contributor.author | Escribano, Pilar | |
dc.contributor.author | Álvarez-Uría, Ana | |
dc.contributor.author | Alonso, Roberto | |
dc.contributor.author | Catalán, Pilar | |
dc.contributor.author | Alcalá, Luis | |
dc.contributor.author | Muñoz, Patricia | |
dc.contributor.author | Guinea, Jesús | |
dc.date.accessioned | 2024-02-05T10:55:22Z | |
dc.date.available | 2024-02-05T10:55:22Z | |
dc.date.issued | 2020-11-16 | |
dc.identifier.other | https://pubmed.ncbi.nlm.nih.gov/33199713/ | es |
dc.identifier.other | https://www.nature.com/articles/s41598-020-76914-5 | es |
dc.identifier.uri | http://hdl.handle.net/20.500.12020/1170 | |
dc.description.abstract | We assessed the performance of Abbott's SARS-CoV-2 IgG assay and the PanbioTM COVID-19 IgG/IgM rapid test device for the diagnosis of either active or cured COVID-19. Three cohorts of patients were chosen. Cohort 1, patients (n = 65) who attended the emergency department on March 30, 2020 with clinical suspicion of active COVID-19 (n = 56 with proven/probable COVID-19). Cohort 2, hospital workers (n = 92) who had either been (n = 40) or not (n = 52) diagnosed with proven/probable COVID-19 and were asymptomatic at the time of the sampling. Cohort 3, patients (n = 38) cared at the hospital before the start of the COVID-19 pandemic. Detection of serum antibodies was done using Abbott´s SARS-CoV-2 IgG assay and the PanbioTM COVID-19 IgG/IgM device. Both methods showed 98% agreement for IgG detection. No antibodies were detected in the 38 samples from hospitalized pre-COVID subjects. The diagnostic performance of IgGs detected by Abbott´s SARS-CoV-2 assay in Cohorts 1/2 was: sensitivity (60.7%/75%) and specificity (100%/84.6%). The diagnostic performance of IgM by PanbioTM COVID-19 in Cohorts 1/2 was: sensitivity (16%/17.5%) and specificity (100%/98.1%). We show that IgG detection alone is insufficient for the diagnosis of active or cured COVID-19. IgM detection has a limited diagnostic value. | es |
dc.language.iso | en | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | Detection of SARS‑CoV‑2 antibodies is insufficient for the diagnosis of active or cured COVID‑19 | es |
dc.type | article | es |
dc.identifier.doi | 10.1038/s41598-020-76914-5 | |
dc.issue.number | 1 | es |
dc.journal.title | Scientific Reports | es |
dc.page.initial | 19893 | es |
dc.page.final | 19893 | es |
dc.rights.accessRights | openAccess | es |
dc.subject.area | Ciencias Biomédicas | es |
dc.subject.keyword | COVID-19 | es |
dc.subject.keyword | SAS-CoV-2 | es |
dc.subject.keyword | IgG | es |
dc.subject.keyword | Diagnosis | es |
dc.subject.keyword | CLIA | es |
dc.subject.unesco | 2414 Microbiología | es |
dc.volume.number | 10 | es |