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E1a is an exogenous in vivo tumour suppressor
dc.contributor.author | Cimas, Francisco J | |
dc.contributor.author | Callejas-Valera, Juan L | |
dc.contributor.author | García-Olmo, Dolores C | |
dc.contributor.author | Hernández-Losa, Javier | |
dc.contributor.author | Melgar-Rojas, Pedro | |
dc.contributor.author | Ruiz-Hidalgo, María J | |
dc.contributor.author | Pascual-Serra, Raquel | |
dc.contributor.author | Ortega-Muelas, Marta | |
dc.contributor.author | Roche, Olga | |
dc.contributor.author | Marcos, Pilar | |
dc.contributor.author | Garcia-Gil, Elena | |
dc.contributor.author | Fernandez-Aroca, Diego M | |
dc.contributor.author | Ramón Y Cajal, Santiago | |
dc.contributor.author | Gutkind, J Silvio | |
dc.contributor.author | Sanchez-Prieto, Ricardo | |
dc.date.accessioned | 2024-02-02T11:49:21Z | |
dc.date.available | 2024-02-02T11:49:21Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Cimas, F. J., Callejas-Valera, J. L., García-Olmo, D. C., Hernández-Losa, J., Melgar-Rojas, P., Ruiz-Hidalgo, M. J., Pascual-Serra, R., Ortega-Muelas, M., Roche, O., Marcos, P., Garcia-Gil, E., Fernandez-Aroca, D. M., Ramón y Cajal, S., Gutkind, J. S., & Sanchez-Prieto, R. (2017). E1a is an exogenous in vivo tumour suppressor. Cancer Letters, 399, 74-81. https://doi.org/10.1016/j.canlet.2017.04.010 | es |
dc.identifier.issn | 0304-3835 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12020/1146 | |
dc.description.abstract | The E1a gene from adenovirus has become a major tool in cancer research. Since the discovery of E1a, it has been proposed to be an oncogene, becoming a key element in the model of cooperation between oncogenes. However, E1a's in vivo behaviour is consistent with a tumour suppressor gene, due to the block/delay observed in different xenograft models. To clarify this interesting controversy, we have evaluated the effect of the E1a 13s isoform from adenovirus 5 in vivo. Initially, a conventional xenograft approach was performed using previously unreported HCT116 and B16-F10 cells, showing a clear anti-tumour effect regardless of the mouse's immunological background (immunosuppressed/immunocompetent). Next, we engineered a transgenic mouse model in which inducible E1a 13s expression was under the control of cytokeratin 5 to avoid side effects during embryonic development. Our results show that E1a is able to block chemical skin carcinogenesis, showing an anti-tumour effect. The present report demonstrates the in vivo anti-tumour effect of E1a, showing that the in vitro oncogenic role of E1a cannot be extrapolated in vivo, supporting its future use in gene therapy approaches. | es |
dc.language.iso | en | es |
dc.publisher | Elsevier | es |
dc.title | E1a is an exogenous in vivo tumour suppressor | es |
dc.type | article | es |
dc.identifier.doi | https://doi.org/10.1016/j.canlet.2017.04.010 | |
dc.journal.title | Cancer Letters | es |
dc.page.initial | 74 | es |
dc.page.final | 81 | es |
dc.rights.accessRights | embargoedAccess | es |
dc.subject.area | Biología Celular y Molecular | es |
dc.subject.area | Ciencias Biomédicas | es |
dc.subject.keyword | E1a | es |
dc.subject.keyword | Adenovirus | es |
dc.subject.unesco | 24 Ciencias de la Vida | es |
dc.volume.number | 399 | es |
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