Elevation of Cardiac Troponins After Endurance Running Competitions
Identificadores
URI: http://hdl.handle.net/20.500.12020/1131ISSN: 0009-7322
DOI: https://doi.org/10.1161/CIRCULATIONAHA.118.034655
Fecha
2019Tipo de documento
articleÁrea/s de conocimiento
Ciencias BiomédicasMateria/s Unesco
2411.06 Fisiología del EjercicioResumen
In the present investigation, we selected 63 healthy runners (in triplets) from a group of 322 nonprofessional finishers because of their similarities in age (mean±SD age, 37±7 years), anthropometry (66.9±12.8 kg), and running experience (3.3±0.2 years). The triplets also had similar 10-year absolute cardiovascular risks (2.8±2.1%) calculated by the non–laboratory-based Framingham function.5 In each group, there were 13 women and 8 men. From each triplet, 1 runner competed in a 10-km race, another in a half-marathon race, and the third in a full marathon race. As would be expected, as a result of the different training patterns for each distance, training volume in the month before the race increased with the competition distance (23.9±9.0, 34.8±8.0, and 40.6±16.4 km/wk for 10-km runners, half-marathoners, and marathoners, respectively; P<0.01). Before and 10 minutes after the race, body mass was measured to assess dehydration. Blood samples were obtained to measure cardiac biomarkers, including high-sensitivity cardiac troponins I and T, NT-proBNP (N-terminal pro-B-type natriuretic peptide), and the cardiac (creatine kinase-MB) and skeletal muscle (creatine kinase-MM) isoenzymes of creatine kinase and myoglobin at the end of the races. The between-group differences in these variables were analyzed by a 2-way ANOVA. The study was approved by the Ethics Committee for Research of the Camilo Jose Cela University. All the research protocols described here were carried out in accordance with the Declaration of Helsinki, and all subjects gave informed consent to participate in the study.