TY - JOUR AU - Blesa, Javier AU - Foffani, Guglielmo AU - Dehay, Benjamin AU - Bezard, Erwan AU - Obeso, José PY - 2022 SN - 1471-003X UR - http://hdl.handle.net/20.500.12020/1524 AB - For the last two decades, pathogenic concepts in Parkinson disease (PD) have revolved around the toxicity and spread of α-synuclein. Thus, α-synuclein would follow caudo-rostral propagation from the periphery to the central nervous system, first... LA - en PB - Nature Research TI - Motor and non-motor circuit disturbances in early Parkinson disease: which happens first? DO - https://doi.org/10.1038/s41583-021-00542-9 T2 - Nature Reviews Neuroscience M2 - 115 KW - Parkinson's Disease KW - Striatum KW - Synuclein KW - Neurodegeneration KW - Substantia Nigra VL - 23 ER -