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dc.contributor.authorMora, Fernando
dc.contributor.authorMolina Martín, Juan de Dios
dc.contributor.authorZubillaga, Elena
dc.contributor.authorLópez-Muñoz, F.
dc.contributor.authorÁlamo González, C
dc.date.accessioned2018-07-09T11:34:09Z
dc.date.available2018-07-09T11:34:09Z
dc.date.issued2015-05-25
dc.identifier.citationMora F, Molina JD, Zubillaga E, López-Muñoz F, Álamo C (2015) CYP450 and Its Implications in the Clinical Use of Antipsychotic Drugs. Clin Exp Pharmacol 5: 176. doi:10.4172/2161-1459.1000176es
dc.identifier.issn2161-1459
dc.identifier.urihttp://hdl.handle.net/20.500.12020/777
dc.description.abstractPolypharmacy implies a high potential for drug-drug interactions. The capacity of the cytochrome P450 enzyme system involved in the metabolism of psychoactive drugs differs greatly, which leads to variable drug elimination rates and inter-subject differences in serum drug concentrations. Polymorphisms in genes coding for CYP450 enzymes contribute to this inter-subject variability. Therapeutic response and adverse effects vary among patients treated with the same dose of a certain drug. Polypharmacy, comorbidity and the use of certain substances (grapefruit juice, caffeine and tobacco) increase the chances of clinically relevant interactions in a psychotic patient. Choosing drugs with low interaction potential seems to be the best strategy to prevent clinically relevant interactions particularly in elderly, polymedicated, oncologic and HIV patients.es
dc.language.isoenes
dc.publisherJun-Ping Liues
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleCYP450 and Its Implications in the Clinical Use of Antipsychotic Drugses
dc.typearticlees
dc.identifier.doi10.4172/2161-1459.1000176
dc.issue.number3es
dc.journal.titleJournal of oJ Clinical and Experimental Pharmacologyes
dc.page.initial1es
dc.page.final4es
dc.rights.accessRightsopenAccesses
dc.subject.areaPsicologíaes
dc.subject.keywordCYP450es
dc.subject.keywordDrug interactionses
dc.subject.keywordAntipsychotices
dc.subject.keywordPharmacokinetices
dc.subject.keywordPolypharmacyes
dc.subject.unesco3201.05 Psicología Clínicaes
dc.subject.unesco3209 Farmacologíaes
dc.volume.number5es


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internacional