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dc.contributor.authorÁlamo González, C
dc.contributor.authorLópez-Muñoz, F.
dc.contributor.authorGarcía-García, P.
dc.contributor.authorGarcía-Ramos, S.
dc.date.accessioned2018-06-27T11:37:22Z
dc.date.available2018-06-27T11:37:22Z
dc.date.issued2014-12
dc.identifier.issn1479-8301
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/25495088es
dc.identifier.urihttp://hdl.handle.net/20.500.12020/770
dc.description.abstractDepression in the elderly is a significant health issue that has the potential to seriously affect physical and emotional well-being. Therefore, the treatment of geriatric depression is necessary. Antidepressant treatment in older depressed patients is efficacious, but differences in the effectiveness of different classes of antidepressants have not been demonstrated. However, differences in tolerability profile are most recognizable in the elderly. With ageing, a series of changes occur in the elderly that modify both the pharmacokinetics and pharmacodynamics of antidepressants and may influence the efficacy, tolerability and safety of treatment in the elderly. Comorbidities require the use of other drugs, which increases the possibility of drug-drug interactions. Given these aspects, individualized therapy for each elderly patient is needed to achieve acceptable risk-benefit ratio. Effective treatment of depression in the elderly, which may require combined pharmacological with psychosocial treatment, can decrease both morbidity and mortality; it also may lead to reduced demands on family members and on health-care and social services.es
dc.language.isoenes
dc.publisherToshihisa Tanakaes
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleRisk-benefit analysis of the antidepressant drug treatment in the elderlyes
dc.typearticlees
dc.identifier.doi10.1111/psyg.12057.
dc.issue.number4es
dc.journal.titlePsychogeriatrics: The Official Journal of The Japanese Psychogeriatric Societyes
dc.page.initial261es
dc.page.final268es
dc.rights.accessRightsopenAccesses
dc.subject.areaPsicologíaes
dc.subject.keywordAntidepressant drugses
dc.subject.keywordDepressiones
dc.subject.keywordElderlyes
dc.subject.keywordRisk-benefit analysises
dc.subject.unesco61 Psicologíaes
dc.subject.unesco3209 Farmacologíaes
dc.volume.number14es


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internacional