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dc.contributor.authorLópez-Muñoz, F.
dc.contributor.authorTorrellas, Clara
dc.contributor.authorCacabelos, Ramón
dc.date.accessioned2018-06-26T15:14:15Z
dc.date.available2018-06-26T15:14:15Z
dc.date.issued2014-04-29
dc.identifier.citationCacabelos, Ramón & Torrellas, Clara & López-Muñoz, Francisco. (2014). Epigenomics of Alzheimer's Disease. Journal of Experimental & Clinical Medicine. 6. 10.1016/j.jecm.2014.03.010.es
dc.identifier.issn1878-3317
dc.identifier.urihttp://hdl.handle.net/20.500.12020/763
dc.description.abstractAlzheimer's disease (AD) is a polygenic/complex disorder in which genomic, epigenomic, and environmental factors are involved. Epigenetic factors have emerged as important mediators of aging, neurodegeneration, and brain disorders. Epigenomic changes underlying the phenotypic expression of AD, represented by deposits of extracellular Aβ aggregates in senile plaques, intracellular neurofibrillary tangles, neuronal loss, dendritic desarborization, and neurochemical alterations are candidate targets for therapeutic intervention. Changes in DNA methylation, histone modifications, chromatin remodeling, and noncoding RNA dysregulation can affect AD-related gene expression, leading to the multistep process of premature neurodegeneration. Epigenetic modifications are reversible and can be potentially targeted by pharmacological and dietary interventions.es
dc.language.isoenes
dc.publisherElsevieres
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleEpigenomics of Alzheimer’s Diseasees
dc.typearticlees
dc.identifier.doi10.1016/j.jecm.2014.03.010
dc.issue.number3es
dc.journal.titleJournal of Experimental and Clinical Medicinees
dc.page.initial75es
dc.page.final82es
dc.rights.accessRightsopenAccesses
dc.subject.areaPsicologíaes
dc.subject.keywordDNA methylationes
dc.subject.keywordEpigeneticses
dc.subject.keywordHistone modificationses
dc.subject.keywordNoncoding RNAses
dc.subject.unesco61 Psicologíaes
dc.volume.number6es


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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