Show simple item record

dc.contributor.authorLópez-Muñoz, F.
dc.contributor.authorCacabelos, Ramón
dc.date.accessioned2018-06-26T13:58:38Z
dc.date.available2018-06-26T13:58:38Z
dc.date.issued2014-02-12
dc.identifier.citationCacabelos R, López-Muñoz F (2014) The ABCB1 Transporter in Alzheimer’s Disease. Clin Exp Pharmacol 4: e128. doi:10.4172/2161- 1459.1000e128es
dc.identifier.issn2161-1459
dc.identifier.urihttp://hdl.handle.net/20.500.12020/761
dc.description.abstractABC genes, especially ABCB1 (ATP-binding cassette, sub-family B (MDR/TAP), member 1; Doxorubicin resistance; Multidrug resistance 1; Multidrug resistance protein 1; P-glycoprotein 1; P glycoprotein 1/ multiple drug resistance 1;P-gp) (7q21.12), ABCC1 (9q31.1), ABCG2 (White1) (21q22.3), and other genes of this family encode proteins which are essential for drug metabolism and transport. The multidrug efflux transporters P-gp, multidrug-resistance associated protein 4 (MRP4) and breast cancer resistance protein (BCRP), located on endothelial cells lining brain vasculature, play important roles in limiting movement of substances into and enhancing their efflux from the brain. Transporters also cooperate with Phase I/Phase II metabolism enzymes by eliminating drug metabolites. Their major features are their capacity to recognize drugs belonging to unrelated pharmacological classes, and their redundancy, by which a single molecule can act as a substrate for different transporters. This ensures an efficient neuroprotection against xenobiotic invasions. The pharmacological induction of ABC gene expression is a mechanism of drug interaction, which may affect substrates of the up-regulated transporter, and over expression of MDR transporters confers resistance to anticancer agents and CNS drugs [1,2]. Mutations in ABC transpoes
dc.language.isoenes
dc.publisherJun-Ping Liues
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleThe ABCB1 Transporter in Alzheimer’s Diseasees
dc.typearticlees
dc.identifier.doi10.4172/2161-1459.1000e128
dc.issue.number2es
dc.journal.titleJournal of oJ Clinical and Experimental Pharmacologyes
dc.page.initial1es
dc.page.final3es
dc.rights.accessRightsopenAccesses
dc.subject.areaPsicologíaes
dc.subject.keywordAlzheimeres
dc.subject.keywordABCB1es
dc.subject.unesco61 Psicologíaes
dc.volume.number4es


Files in this item

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internacional