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dc.contributor.authorDel Coso, J.
dc.contributor.authorLara, B
dc.contributor.authorSalinero, J.J.
dc.contributor.authorAreces, F.
dc.contributor.authorRuiz-Vicente, D.
dc.contributor.authorGallo-Salazar, C.
dc.contributor.authorAbián-Vicen, J.
dc.contributor.authorCacabelos, Ramón
dc.identifier.citationDel Coso, J., Lara, B., Salinero, J. J., Areces, F., Ruiz-Vicente, D., Gallo-Salazar, C., Abián-Vicén, J. and Cacabelos, R. (2016), CFTR genotype-related body water and electrolyte balance during a marathon. Scand J Med Sci Sports, 26: 1036–1044es
dc.description.abstractThe aim of this investigation was to determine the influence of CFTR genotype on body water and electrolyte balance during a marathon. Fifty-one experienced runners completed a marathon race. Before and after the race, body mass and a sample of venous blood were obtained. During the race, sweat samples were collected using sweat patches, and fluid and electrolyte intake were obtained using self-reported questionnaires. Thirty-eight participants (74.5% of the total) were 7T/7T homozygotes, 11 (21.6%) were 7T/9T heterozygotes, and one participant presented the rare genotype 5T/7T. Another participant with 9T/9T presented the mutation p.L206W. Participants with 7T/7T showed higher sweat sodium concentrations (42.2 ± 21.6 mmol/L) than 7T/9T (29.0 ± 24.7 mmol/L; P = 0.04). The runner with the 5T/7T genotype (10.2 mmol/L) and the participant with the p.L206W mutation (20.5 mmol/L) exhibited low-range sweat sodium concentrations. However, post-race serum sodium concentration was similar in 7T/7T and 7T/9T (142.1 ± 1.3 and 142.4 ± 1.6 mmol/L, respectively; P = 0.27) and did not show abnormalities in participants with the 5T/7T genotype (140.0 mmol/L) and the p.L206W mutation (143.0 mmol/L). Runners with the CFTR-7T/7T genotype exhibited increased sweat sodium concentrations during a marathon. However, this phenotype was not related with increased likelihood of suffering body water and electrolyte imbalances during real
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.titleCFTR genotype-related body water and electrolyte balance during a marathones
dc.journal.titleScand J Med Sci Sportses
dc.subject.areaCiencias de la Actividad Física y del Deportees
dc.subject.keywordcystic fibrosises
dc.subject.keywordendurance exercisees
dc.subject.unesco3201.99 Otras

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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internacional