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Diet, Microbiota, and Colorectal Cancer

dc.contributor.authorBrandt, Marta
dc.contributor.authorGrazioso, Tatiana P.
dc.contributor.authorDjouder, Nabil
dc.date.accessioned2026-02-26T15:24:29Z
dc.date.available2026-02-26T15:24:29Z
dc.date.issued2019
dc.identifier.citationGrazioso, T. P., Brandt, M., & Djouder, N. (2019). Diet, microbiota, and colorectal cancer. Iscience, 21, 168-187. https://doi.org/10.1016/j.isci.2019.10.011es
dc.identifier.issn2589-0042
dc.identifier.urihttp://hdl.handle.net/20.500.12020/1965
dc.description.abstractThe intestinal epithelium is a very dynamic tissue under a high regenerative pressure, which makes it susceptible to malignant transformation. Proper integration of various cell signaling pathways and a balanced cross talk between different cell types composing the organ are required to maintain intestinal homeostasis. Dysregulation of this balance can lead to colorectal cancer (CRC). Here, we review important insights into molecular and cellular mechanisms of CRC. We discuss how perturbation in complex regulatory networks, including the Wnt, Notch, BMP, and Hedgehog pathways; and how variations in inflammatory signaling, nutrients, and microbiota can affect intestinal homeostasis contributing to the malignant transformation of intestinal cells.es
dc.language.isoenes
dc.publisherCell Presses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleDiet, Microbiota, and Colorectal Canceres
dc.typearticlees
dc.identifier.doihttps://doi.org/10.1016/j.isci.2019.10.011
dc.issue.number21es
dc.journal.titleiSciencees
dc.page.initial168es
dc.page.final187es
dc.rights.accessRightsopenAccesses
dc.subject.areaCiencias Biomédicases
dc.subject.keywordDietes
dc.subject.keywordMicrobiotaes
dc.subject.keywordColorectal canceres
dc.subject.unesco32 Ciencias Médicases
dc.volume.number21es


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