Antioxidant Lifestyle, Co-Morbidities and Quality of Life Empowerment Concerning Liver Fibrosis

Abstract

A cross-sectional study including 116 consecutive Internal Medicine outpatients evaluated the association between liver fibrosis estimated by the FIB-4 index and lifestyle-related antioxidant habits, comorbidity burden and quality of life (SF-36 domains). Univariate and multivariate analyses demonstrated significant associations between FIB-4 and four SF-36 domains (Physical QoL, Physical Role, Social QoL and General QoL) as well as the Physical summary score (p < 0.05). Significant interactions were identified between comorbidity, antioxidant lifestyle and FIB-4 in predicting overall quality of life (p < 0.01). These findings support a conceptual model linking subclinical liver fibrosis, oxidative lifestyle patterns and health empowerment in individuals without known liver disease, contributing to personalized preventive strategies in Internal Medicine.