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The interaction between endogenous calcineurin and the plasma membrane calcium-dependent ATPase is isoform specific in breast cancer cells

dc.contributor.authorHolton, MaryLouisa
dc.contributor.authorYang, Di
dc.contributor.authorWang, Weiguang
dc.contributor.authorMohamed, Tamer M. A.
dc.contributor.authorNeyses, Ludwig
dc.contributor.authorArmesilla, Angel L.
dc.date.accessioned2025-05-28T17:00:35Z
dc.date.available2025-05-28T17:00:35Z
dc.date.issued2007
dc.identifier.citationHolton, M., Yang, D., Wang, W., Mohamed, T. M., Neyses, L., & Armesilla, A. L. (2007). The interaction between endogenous calcineurin and the plasma membrane calcium-dependent ATPase is isoform specific in breast cancer cells. FEBS letters, 581(21), 4115-4119. https://doi.org/10.1016/j.febslet.2007.07.054es
dc.identifier.issn0014-5793
dc.identifier.urihttp://hdl.handle.net/20.500.12020/1662
dc.description.abstractPlasma membrane calcium/calmodulin-dependent ATPases (PMCAs) are high affinity calcium pumps that extrude calcium from the cell. Emerging evidence suggests a novel role for PMCAs as regulators of calcium/calmodulin-dependent signal transduction pathways via interaction with specific partner proteins. In this work, we demonstrate that endogenous human PMCA2 and -4 both interact with the signal transduction phosphatase, calcineurin, whereas, no interaction was detected with PMCA1. The strongest interaction was observed between PMCA2 and calcineurin. The domain of PMCA2 involved in the interaction is equivalent to that reported for PMCA4b. PMCA2-calcineurin interaction results in inhibition of the calcineurin/nuclear factor of activated T-cells signalling pathway.es
dc.language.isoenes
dc.publisherWileyes
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleThe interaction between endogenous calcineurin and the plasma membrane calcium-dependent ATPase is isoform specific in breast cancer cellses
dc.typearticlees
dc.identifier.doihttps://doi.org/10.1016/j.febslet.2007.07.054
dc.issue.number21es
dc.journal.titleFEBS Letterses
dc.page.initial4115es
dc.page.final4119es
dc.rights.accessRightsopenAccesses
dc.subject.areaBiología Celular y Moleculares
dc.subject.areaCiencias Biomédicases
dc.subject.keywordPMCAes
dc.subject.keywordCalcineurinaes
dc.subject.keywordInteractiones
dc.subject.keywordMCF-7es
dc.subject.keywordSignallinges
dc.subject.keywordNFATes
dc.subject.unesco32 Ciencias Médicases
dc.subject.unesco2302.21 Biología Moleculares
dc.volume.number581es


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