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Disulfiram/copper complex inhibiting NFkappaB activity and potentiating cytotoxic effect of gemcitabine on colon and breast cancer cell lines

dc.contributor.authorGuo, Xiaoxia
dc.contributor.authorXu, Bing
dc.contributor.authorPandey, Shuchita
dc.contributor.authorGoessl, Elisabeth
dc.contributor.authorBrown, James
dc.contributor.authorArmesilla, Angel L.
dc.contributor.authorDarling, J. L.
dc.contributor.authorWang, Weiguang
dc.date.accessioned2025-01-21T17:18:10Z
dc.date.available2025-01-21T17:18:10Z
dc.date.issued2010
dc.identifier.citationGuo, X., Xu, B., Pandey, S., Goessl, E., Brown, J., Armesilla, A. L., ... & Wang, W. (2010). Disulfiram/copper complex inhibiting NFκB activity and potentiating cytotoxic effect of gemcitabine on colon and breast cancer cell lines. Cancer letters, 290(1), 104-113. https://doi.org/10.1016/j.canlet.2009.09.002es
dc.identifier.issn0304-3835
dc.identifier.urihttp://hdl.handle.net/20.500.12020/1560
dc.description.abstractMost of the gemcitabine (dFdC) resistant cell lines manifested high NFkappaB activity. The NFkappaB activity can be induced by dFdC and 5-FU exposure. The chemosensitizing effect of disulfiram (DS), an anti-alcoholism drug and NFkappaB inhibitor, and copper (Cu) on the chemoresistant cell lines was examined. The DS/Cu complex significantly enhanced the cytotoxicity of dFdC (resistant cells: 12.2-1085-fold) and completely reversed the dFdC resistance in the resitant cell lines. The dFdC-induced NFkappaB activity was markedly inhibited by DS/Cu complex. The data from this study indicated that DS may be used in clinic to improve the therapeutic effect of dFdC in breast and colon cancer patients.es
dc.language.isoenes
dc.publisherElsevier Ireland Ltdes
dc.titleDisulfiram/copper complex inhibiting NFkappaB activity and potentiating cytotoxic effect of gemcitabine on colon and breast cancer cell lineses
dc.typearticlees
dc.identifier.doihttps://doi.org/10.1016/j.canlet.2009.09.002
dc.issue.number1es
dc.journal.titleCancer Letterses
dc.page.initial104es
dc.page.final113es
dc.rights.accessRightsclosedAccesses
dc.subject.areaCiencias Biomédicases
dc.subject.keywordNFkBes
dc.subject.keywordDisulfirames
dc.subject.keywordGemcitabine Resistancees
dc.subject.keywordColorectal Canceres
dc.subject.keywordBreast Canceres
dc.subject.unesco32 Ciencias Médicases
dc.volume.number290es


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