Levodopa-Induced Dyskinesia Is Associated with Increased Thyrotropin Releasing Hormone in the Dorsal Striatum of Hemi-Parkinsonian Rats

Cantuti Castelvetri, Ippolita; F. Hernandez, Ledia; Keller-McGandy, Christine E; Kett, Lauren E.; Landy, Alex; Hollingsworth, Zane R; Saka, Esen; Crittenden, Jill R; Nillni, Eduardo A; Young, Anne B; Standaert, David G; Graybiel, Ann M

doi:https://doi.org/10.1371/journal.pone.0013861

Identificadores

URI: http://hdl.handle.net/20.500.12020/1219
ISSN: 1932-6203
DOI: https://doi.org/10.1371/journal.pone.0013861

Autor/es

Cantuti Castelvetri, Ippolita; F. Hernandez, Ledia; Keller-McGandy, Christine E; Kett, Lauren E.; Landy, Alex; [et al.]

Fecha

2010-11-10

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article

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Resumen

Dyskinesias associated with involuntary movements and painful muscle contractions are a common and severe complication of standard levodopa (L-DOPA, L-3,4-dihydroxyphenylalanine) therapy for Parkinson's disease. Pathologic neuroplasticity leading to hyper-responsive dopamine receptor signaling in the sensorimotor striatum is thought to underlie this currently untreatable condition.

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