Levodopa-Induced Dyskinesia Is Associated with Increased Thyrotropin Releasing Hormone in the Dorsal Striatum of Hemi-Parkinsonian Rats

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URI: http://hdl.handle.net/20.500.12020/1219
ISSN: 1932-6203
DOI: https://doi.org/10.1371/journal.pone.0013861
Author/s
Cantuti Castelvetri, Ippolita; F. Hernandez, Ledia; Keller-McGandy, Christine E; Kett, Lauren E.; Landy, Alex; [et al.]
Date
2010-11-10
Document type
article
Área/s de conocimiento
Ciencias Biomédicas
Materia/s Unesco
32 Ciencias Médicas
2490.02 Neuroquímica
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Abstract
Dyskinesias associated with involuntary movements and painful muscle contractions are a common and severe complication of standard levodopa (L-DOPA, L-3,4-dihydroxyphenylalanine) therapy for Parkinson's disease. Pathologic neuroplasticity leading to hyper-responsive dopamine receptor signaling in the sensorimotor striatum is thought to underlie this currently untreatable condition.
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