TY  - JOUR 
AU  - Orbe, Josune
AU  - Rodríguez, Jose Antonio
AU  - Sánchez-Arias, Juan Antonio
AU  - Salicio, Agustina
AU  - Belzunce, Miriam
AU  - Ugarte, Ana
AU  - Chang, Haysul
AU  - Rabal, Obdulia
AU  - Oyarzabal, Julen
AU  - Páramo, Jose Antonio
PY  - 2105
UR  - http://hdl.handle.net/20.500.12020/1232
AB  - Discovery of potent and safe therapeutics that improve upon currently available antifibrinolytics, e.g., tranexamic acid (TXA, 1) and aprotinin, has been challenging. Matrix metalloproteinases (MMPs) participate in thrombus dissolution. Then we...
LA  - en
PB  - Hans Publishers
TI  - Discovery and safety profiling of a potent preclinical candidate, (4-[4-[[(3R)-3-(hydroxycarbamoyl)-8-azaspiro[4.5]decan-3-yl]sulfonyl]phenoxy]-N-methylbenzamide) (CM-352), for the prevention and treatment of hemorrhage
DO  - 10.1021/jm501939z
T2  - Journal of Medicinal Chemistry
M2  - 2941
KW  - hemorrhage
KW  - metalloproteinases inhibitors
VL  - 58
ER  -