TY - JOUR AU - Crittenden, Jill R AU - Cantuti Castelvetri, Ippolita AU - Saka, Esen AU - Keller-McGandy, Christine E AU - F. Hernandez, Ledia AU - Kett, Lauren E. AU - Young, Anne B AU - Standaert, David G AU - Graybiel, Ann M PY - 2009 SN - 0027-8424 UR - http://hdl.handle.net/20.500.12020/1220 AB - Voluntary movement difficulties in Parkinson's disease are initially relieved by l-DOPA therapy, but with disease progression, the repeated l-DOPA treatments can produce debilitating motor abnormalities known as l-DOPA-induced dyskinesias. We show... LA - en PB - National Academy of Sciences TI - Dysregulation of CalDAG-GEFI and CalDAG-GEFII predicts the severity of motor side-effects induced by anti-parkinsonian therapy. DO - https://doi.org/10.1073/pnas.0812822106 T2 - Proceedings of the National Academy of Sciences (PNAS) M2 - 2892 KW - ERK KW - L-DOPA KW - Parkinson’s disease KW - Striatum KW - Dyskinesia VL - 106 ER -